Effect of oyster mushroom mycelial water extract on total blood cholesterol level of

International Conference on Mathematics and Natural Sciences, 29-30 Nov. 2006, Bandung West Java. P. 160.

Afifah BS.1,2, INP. Aryantha1, Suswini K.1, Yuli S.21. Center for Life Science ITB, Jalan Ganesha 10 Bandung 401322. Department of Pharmacy UNJANI, Jl. Terusan Jenderal Sudirman Cimahi

ABSTRACT

A study on the effect of oyster mushroom (Pleurotus ostreatus) mycelial water extract on total blood cholesterol level has been conducted using Wistar female rats with high cholesterol diet and prophylthiouracil (PTU) as hypercholesterolemic inducing agent. The animal were divided into two dose-level groups and one control group, each group consists of six rats. In the cholesterol inhibition method, both high cholesterol diet and PTU were administered simultaneously with the mycelial extract orally. In the cholesterol reducing method, high cholesterol diet and PTU were given over 4 weeks and then followed by anticholesterol treatment with the mycelial extract. Two doses level of the mycelial extract, 55 and 110 mg/kg body weight were applied respectively. Total blood cholesterol level was observed once a week over 4 weeks. As hypercholesterolemic inhibitor, the both doses level relatively could inhibit about 9.34% and 9.61% respectively the increasing of cholesterol level significantly (P=0.05) at day-21 (3rd week) compared with control. As hypercholesterolemic reducer, 110 mg/kg body weight of the mycelial extract could reduce relatively about 59.73% hypercholesterolemia at day-7 (1st week) compared with control. It can be concluded that the mycelial water extract of oyster mushroom was able to inhibit and to reduce relatively hypercholesterolemia in female rats.
-------------------------------------------------------------------------------------------Keywords : oyster mushroom, mycelial water extrac, hypercholesterolemia